Hospital-acquired infections (HAIs) are associated with increased morbidity, mortality, and healthcare costs worldwide. Effective hand hygiene practices are critical for preventing HAIs, yet compliance among healthcare workers remains suboptimal. This study assessed the impact of a structured hand hygiene campaign in three tertiary care hospitals over a six-month period. Interventions included educational workshops, visual reminders, provision of hand sanitizers, and regular compliance monitoring. HAI rates were recorded for bloodstream infections, urinary tract infections, and surgical site infections. Results demonstrated a 32% increase in hand hygiene compliance among healthcare workers and a corresponding 20% reduction in HAIs (p<0.01). Subgroup analysis showed that surgical wards experienced the greatest reduction (28%) in infection rates. Surveys revealed that healthcare workers reported improved awareness and perceived personal responsibility for infection prevention. These findings underscore the effectiveness of targeted, multi-component hand hygiene campaigns in enhancing patient safety and reducing HAIs, highlighting the need for sustainable infection control programs across healthcare facilities.

Keywords:
Hand Hygiene, Hospital-Acquired Infections, Infection Control, Patient Safety, Public Health