Vaccine hesitancy poses a significant barrier to achieving high immunization coverage, particularly in low-income urban settings. This cross-sectional study explored socio-demographic, behavioral, and informational determinants of vaccine hesitancy among 800 adults in three low-income urban neighborhoods. Using structured questionnaires and focus group discussions, the study found that misinformation, distrust in healthcare providers, and perceived low susceptibility to infectious diseases were major contributors to vaccine hesitancy. Educational level and prior experience with vaccination campaigns were positively associated with vaccine acceptance. Interventions tailored to address misinformation and improve healthcare trust are critical to increasing vaccine uptake in underserved urban populations.

Keywords:
Vaccine Hesitancy, Immunization, Public Health, Urban Health, Health Behavior